I have six .22 pistols, my favorite has to be my first, a Ruger Standard (circa 1978):
Actually this was my 2nd Standard. Like the idiot I am I sold my first one (with the red emblem and wood grips) to a neighbor for what I bought it for back in 1967. I'm still kicking myself.
I also have a Colt Woodman 2nd Series that belonged to my mother-in-law. Both guns shoot well, but the sentimental favorite is the Ruger.
I have a GSG Firefly and a 1911 in .22, also a Bersa Thunder .22. I like them fine but they're not as accurate (except maybe the 1911) as the Ruger or Colt. All 3 need to be fed high velocity ammo, I'm currently using Fiocchi and have very few failures.
As far as take down goes, practice makes perfect. I don't cuss nearly as much these days when cleaning the Ruger.
Of all I mentioned, the Firefly feels the best in my hand and with a steady hand is a fine shooter.
My 6th is a Heritage Rough Rider, shoots fine but I rarely take it to the range.