Technique and Training
The battle has been raging a long time as to what is the "Best" stance, grip, etc., Iso, Weaver, Chapman, etc. After 20+ years in Law Enforcement I've seen lots of instructors come and go, many claiming superiority in practice and technique.
I've found that it really dosen't matter what you call it as long as it works well for you. Some shooters do better with one, while others are more proficient with another. I think some of the difference has to do with an individuals body type/structure (build, musculature, agility, mobility, etc.), and their individual ability to incorporate a given technique to their physical limitations (and we all have limitations).
When I see someone who is of a similar build(heavy, thin, medium etc.), and is able to consistently perform at a high level, I observe to see if they're doing something that might aid in my own practice. Not to say that I would just abandon all my prior training and experience, but just be open to new ideas and techniques. I will try them later when I'm able to see how they work for me, sometimes I keep them and sometimes I discover they just don't work well for me.
I guess what I'm suggesting is that you continue to use the solid base you've acquirred (stable platforms, mobile platforms, grips, etc.), and mix the practice (stationary shooting, moving drills, cover and concealment, etc.) relying on the techniques that prove to be effective for you.
In a home /self defense situation there no "BEST" rule or technique, simply because you never know what the circumstances might be when/if an incident happens. Therefore its best to practice a variety of skills and try to remain fluid and flexible in your approach. If you are able to limit the variables in a "self-defense" scenario, then your ahead of the game and able to somewhat plan your strategy, but normally we don't have the luxury of foreknowledge, just the foresight to train and be as prepared as possible.
Good Luck