My shooting buddies and I usually run through some standard practice drills, normally a variation of the Front Sight or ASAA defensive pistol graduation standards. These involve speed work from the holster, pairs to COM, head shots, speed/tactical reloads, etc. from contact distance to 25 meters.
Then we usually move on to some box drills and snakes - these are movement drills with multiple targets.
Finally, we shoot 4-5 defensive scenarios, usually with multiple targets, props, vehicles, etc. Sometimes we'll do the scenarios first, to get an idea of how we shoot "cold," without any warm-up shooting practice.
We use IPSC cardboards for targets, and usually put old t-shirts over them for the scenario shooting. I have an electronic shot timer, my own target stands, and a wide open desert.