Yes, using .45 ACP cartridges will require the use of clips, 1/2-moon or full-moon.
S&W's "Governor" is no better an idea than Taurus's "Judge." It's merely more expensive.
The .410 shotgun shell, regardless of what comes out of it, is inadequate for self-protection. The .45 "Long" Colt and the .45 ACP deliver very similar ballistics, although the .45 "Long" Colt delivers a heavier bullet going slightly slower.
But if you're going to shoot .45 "Long" Colt or .45 ACP cartridges, why not start off with a pistol that fires one of them (or both) out of a properly-sized cylinder, rather than the inaccuracy-promoting, too-long cylinders of the "Governor" and the "Judge"?
Both the "Governor" and the "Judge" are merely gimmicks, their design criteria being to part you from your money. The only beneficiary, were you to buy one, would be the manufacturer's sales force.