Packard and Dave;
If you wish to use either the .45 ACP or the .45 "Long" Colt round, why buy a Governor? Instead, buy a pistol that is purpose-chambered for the round you want to use.
Because of its long cylinder, the shorter .45 ACP and .45 "Long" Colt rounds will not perform anywhere nearly as well in a Governor as they would in a properly-chambered pistol.
I suggest that the only practical reason to own a Governor is to use .410 shotshells in it. Its "convertability" is a mirage meant only to bolster sales.
But even when using .410 shotshells, the Governor is at a disadvantage because its rifled barrel causes bird- and buck-shot to disperse too quickly and relatively uncontrollably. Further, even the special "antipersonnel" loads sold for use in it lack adequate fight-stopping penetration. Thus, it is a very-close-range-only weapon, best suited, perhaps, to dispatching snakes.
Rather than relying upon "the shotgun effect" promised by the Governor (and, by extension, the Judge), a more practical approach would be to invest your time in learning to shoot any really effective defensive pistol well enough to assure yourself that you can stop any fight in which someone else involves you.
There are no "miracle cures" which will absolve you from practicing to become an effective, accurate pistol shooter.
The "shotgun effect" is a mirage, and will not save your life in a time of need.