My P250 2Sum have proven to be great guns. No problem moving the fire control unit. Once you get the hang of it, it only takes a minute. Never had and issues, great pistol.
I also own a P2022 and that is also a great gun, but for me a little too big to carry concealed, but great to shoot at the range.
I recently bought a P290RS and that is an amazing shooter for a short pistol. I had some problems with light strikes but straightened out after a few magazines.
I don't think you could go wrong with any of these, but they are all a little different. I think the thing is what do you want to do with this pistol, shoot it or carry it. My feeling is all of the pistols you mention come with bragging rights that you own a really nice, really reliable pistol! After all they are Sigs!