I own two of them. It takes a little getting used to but being left handed I've been adapting to a right handed world all my life. It's just another thing to get used to is all. I love both my Sigs. (226 9mm & 229 .40s&w) and would not trade them for anything. And I'm mainly a 1911 guy!
With some time invested in training with the weapon you can use it as good as anyone else right handed or not.