I own a S&W MP9, Sig P225/P6, Sig Mosquito, Ruger MKII 22lr, S&W 30-1 (32 long). If I could'nt carry the P6, I would carry Mosquito with CCI stingers.
So now you know my favorites. First you don't want a gun that doesnt feel good and or you can't hit anything with. Find out as much as you can about any issues (google is you friend). Choose your caliber with caution, how many people or walls will the bullet pass through before it stops. IMO sig is the way to go never put a price of your safety. Remember a well placed rock will also drop a 300lb man.