Which one weighs more?
I shoot both 45 and 9mm. The 45 (in an XD) has a very managable recoil, and both the 220 Supermatch and X-Five are heavier than my XD. Second, if you're shooting bullseye, "flippiness" isn't an issue, since speed isn't an issue. If you're shooting IDPA, where it's all speed, then figure based on class (custom or stock, high capacity or 10-shot) etc, etc. They shoot mainly 9mm and .40S&W based on capacity.
Accuracy? Both are factory "fitted/matched" guns, and exceptional. The 45 just makes a bigger hole... lol
If it's for shooting little ragged holes for fun, both fit the bill. The 9mm ammo is much cheaper, the the X-Five is a lot more money???