I am as puzzled as Jake, because there is such a world of difference between your original choice of the .380 ACP cartridge and your final decision to purchase a .22 rimfire gun.
The .380 is a self-defense cartridge. The .22 rimfire is definitely not a practical self-defense cartridge. (It is, however, a pretty good learning-to-shoot cartridge.)
A wiser man than I once said: "Before making any decision, first you need to figure out exactly what it is that you're trying to accomplish."