Sounds like a fun and productive range trip.
On your Glock, I say if you're not happy with the placement of the group, but the group size is good/great and there seem to be few flyers scattered out near the edge, then go ahead and make a sight adjustment. Most Glocks are rough-zeroed pretty close, but I've seen a rare few that were quite a bit "off" right out of the box (Friday afternoon guns?). Small group size and few flyers are both signs of consistent and proper application of the fundamentals of shooting, so don't be too concerned about doing a little tap-tap-tapping on that rear sight to get those shots closer to center.
About the 10/22 safety: I've also experienced this, but only once, right after take-down and reassembly. During reassembly, when you put it back into the stock, the safety button has to be centered (halfway-on/halfway-off)to allow it to pass though the stock without damaging the wood on either side. If it is left in this centered position (or somehow gets there due to side pressure from a gun case, inadvertent movement during handling, etc.), then it will function properly for a few shots before shooting-induced vibration finally causes the safety to snap into one of the detent positions; either full-off or full-on-safe. I suggest double-checking the position of the safety prior to shooting, and making sure it's fully off-safe prior to starting a string of fire. If it seems like it moving sluggishly or not snapping solidly into both positions, put a drop of lube on the edge of the safety button and work it on and off a few hundred times; THAT should smooth it out.