I would go for the NEOS,,,
I own three NEOS pistols and a Carbine kit,,,
I much prefer them over the 22A a friend of mine has.
I have literally thousand of rounds through each frame,,,
I have had no problems with either of the three guns.
My friend has the 22A,,,
He has to replace the recoil buffer quite often,,,
It's an easy thing to do and they are inexpensive parts to obtain,,,
But my thinking is that a new designed pistol should not have disposable parts.
Also, the Beretta magazines are the best I have ever seen for any .22 pistol,,,
The metal mags have a BIG button allowing for very easy loading,,,
The only drawback to this is your ammo will go quick. :mrgreen:
The Beretta's are very modular,,,
Extra barrels can be had for about $65.00.
One friend has a 6" barrel with a red dot mounted for small game,,,
When he just wants to casually plink he swaps to the 4.5" barrel in 60 seconds flat.
People sometimes tease me about my "space cadet" pistols,,,
But then I just outshoot them and they quickly shut up.
The only drawback to the NEOS is it has very slender grips,,,
Many of my ham-fisted friends say they are too small,,,
The S&W 22A has a fat grip they would like better.
Hope this helps,,,