Mine actually started with a .40 cal. She tagged along when I started shooting IDPA. She did some shooting after the match, then ended up shooting the matches with me. She preferred the 9mm, so I set her up with a Walther P99. She loves the trigger and it doesn't aggravate her arthitis. Anyway, my point is let her try different handguns until she finds one she like the most. Most women prefer the 9, but I know plenty who love shooting the .45. Definitly get a .22. It's a great tool for learning the basics, as well as being cheap and fun to shoot. Keep us posted.