Well I have the 50'ish eyes that I require reading glasses but my long distance vision is fine. I have no problem sighting in my target.
First I'm not sure what you are trying to describe here but I can just guess - when you are looking at your sights the target is fuzzy - if that is the case welcome to the club it is normal. No one's eyes can focus on 2 seperate objects seperated by distance. In other words if you are looking at your sights the target appears fuzzy or vice versa.
Now if you are asking how to sight your weapon for me I align the sights on the fuzzy target. To increase your speed, with practice you obtain muscle memory and procedure to just use the front sight for firing.
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