Yes, if you can find a Smith & Weeson 3913. It is small enough for carry, big enough to shoot comfortably, and it does have a manaual safety.
I think that would be a good good for your wife. On a side note, I strongly urge you to not leave a gun in the car. If the weapon is carried outside the the home, it should be on a person. Some may disagree with this but please consider it.