I have a CZ-75B in 9mm, and the Kadet .22 conversion kit for it. It is an almost perfect practice combo. The 9mm is capable of 2" groups at 25 yards, from the factory, and the .22 is also very accurate. It is an all steel gun with a ~5" barrel, and can be operated from the cocked and locked position, like a 1911, or fired double-action (first shot) like other popular self-defense handguns. Mine (in 9mm) has never even 'burped,' after a couple thousand rounds of the cheapest ammo I can find, or with premium JHP's.
I typically take several handguns to the range and fire as many rounds as I can afford in the center fire calibers. Then, I finish up by sticking the .22 slide on the CZ (takes 30 seconds) and shooting bulk pack .22 ammo until my hands start cramping from loading magazines. It's a great way to get lots of repetition.
The CZ is a very fine pistol at a fair price, about $450, plus ~$250 if you want to add the .22 conversion kit.