I base my caliber on what I shoot well and my shot placement on meat damage. When 150 yards or less on a deer I will always try to make a neck shot. On Elk mostly the same. Over 150 yards I choose a caliber that will not only kill the animal but knock it down. Under 150yards I use a 30/30 or a .308 for longer range I use the .06 or a 300 Win. I have killed manymany animals and have lost very liitle meat due to damage from my shot.
I love to hunt and I love to bring home dinner.