I assume your question is regarding the fatigue to a striker spring by being continually loaded (cocked), and therefore compressed.
In answer? NO.
Springs fatigue through many many cycles, not under compression. Like a mag spring, leaving the mag loaded does not fatigue the spring. Repeatedly loading and unloading the mag, by shooting, or by hand, will fatigue the spring.
But in a carry gun that is not shot hundreds of rounds per week, I think every few years is fine. Not sure what the lifecyle of a striker spring is, but one guy (www.pistol-training.com) has shot a S&W M&P striker-fired gun now some 60,000+ rounds, and I don't think he's changed the spring... Maybe once? The slide broke at about 62,000 rounds, and the stopped the test...
Don't worry about it.