Originally Posted by Cat

You guys got me thinking so much in this lol, I read a lot and do a lot with my RO at the range.( RO is Range Officer ) So I was looking on some place I was reading up on this.( The why and why not ) My be this can help. FBI Site.
FBI Handgun Wounding Factors and Effectiveness - FirearmsTactical.com

That was an interesting read. Thanks for posting the paper! As far as the science behind caliber choice, I guess it really comes down to what you can shoot proficiently under duress. I'm a .45 ACP person as the best defensive weapon. However, if I tell a potential buyer that the .45 is the best, but the person hasn't fired a large bore handgun, it may be that the person never really masters the thing. So...if you can master a .380 and that's it, that's what you use for self defense. You have to hit what you're shooting at to save your bacon. Theory goes out the window.

David