To me, 10mm in a full-size pistol feels about the same as .45ACP is a smaller gun. It's a little sharper due to the higher pressures, but not a big deal for an experienced shooter. The Glocks in 10mm are pretty big beasts, though, with very large grips.
I personally see little use for the 10mm, except maybe as a combo outdoorsman/defense gun. (The ghost of Jeff Cooper will probably now strike me dead.)