As you said(and I an assuming here that by 22A you mean the S&W 22A Pistol) both are from good companies with good service reputations, if it is ever needed. Only real difference I am aware of is the modular nature of the Barretta Neos with its additional parts like the carbine kit as well as others. Both have mostly positive reviews(that I have seen) I have not shot a Neos so I am only going on what I have read about them, I do have a S&W 22A that my wife likes to shoot and it seems to be a decent overall pistol, haven't had any problems with it and as most .22 seems more accurate then the shooters I have let use it(at 50 feet off a bench it will hold the 10 ring of standard 50 foot target) nor is it hard to clean.


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