No difference in price. No difference in reliability. A lot depends on your hand size and whether you can be happy with two fingers or three fingers support underneath when you're firing... (pinkie grabbing or pinkie not grabbing). Best thing is to go to a range that rents both and try them out. While you're there or in a friendly gun store, you might as well handle some other similar alternatives also. You might find something that feels better. In the same price and reliability class, I prefer the look and feel of Kahrs over Glocks... but they're very comparable... S&W M&P also (Compacts especially nice for me). If I was only going to have one pistol, yeah, I'd definitely go with a smaller one that I can comfortably carry despite having less round capacity. Extra magazines are quite easy to carry.
BTW, Genitron is a very handy tool for researching and comparing handguns: