Criminals picking/breaking into locked safe:
If your guns are not currently in a safe, they're less than a combination lock away from causing danger. Hiding things is pretty much a futile effort to a career thief. They know where to look for stuff, it really doesn't slow them down to check the well documented places(in their circles) that people "hide" stuff. Unless you're going with fake panel walls that are well hidden to the point of being totally unnoticeable or require some sort of action to open, hiding stuff is a waste of time.
Guns are locked up and you'd have to open the safe to defend yourself if criminals came into your home:
Keep a defensive firearm at arms length, get a concealed carry permit if your state allows it (shouldn't be needed in your own home, but check local regs). Being unarmed in your home because we "think" we're safe is exactly what these home invasion jokers are counting on.