I have several revolvers in .45 Colt, .45 ACP and convertibles. I think the main problem with .45 ACP or .45 AR in a long cylinder revolver isn’t the long jump in the cylinder, but the long jump in an oversize chamber. My S&W 25-2 has .455” throats. It shoots most loads well, but some can be pretty bad. I have a 625-8JM. It has .452” throats and seems to shoot everything well.
My Rugers in .45 Colt have had the throats opened to .452”, Blackhawks and Redhawk. The Redhawk is a very strong revolver, even stronger than the Blackhawk. I have no reservations about using reasonable +P loads in it. The .45 Colt in S&W revolvers, IMO, has no advantage over the .45 ACP due to the limitations of the S&W revolver.
For those who use the .45 Colt in CAS, and want to use light loads, might be better served with .45 AR or this new case which has the .45 Colt rim on a .45 ACP length case. Small charges of fast powders in large cases has the potential for disaster.