I can't imagine a reason on God's green earth you'd need more power than a full-house .357 for home defense. It's been efficiently decking bad guys since 1935. It also comes in slicker and handier guns, and recoils considerably less than a full-house .41. Load with the revered 125 grain JHP and you'll be fine. Practice frequently, because even this load kicks a bit, is loud, and flashes pretty brightly.
If you absolutely need maximum power to flatten someone with a single shot, a blast from a 12 gauge is far better than any handgun, regardless of caliber.
I prefer quieter, less flashy handgun rounds for defense, as opposed to magnums.