I think this depends in large part on your weapon. Full house .357 magnums are pretty controllable in a L frame Smith or Ruger Gp100. The same round could be a real hand full in a Smith Model 60. In my 2 1/2 inch K frame Smith's I keep them stocked with 110 grain magnum rounds when I can find them 38 Special when I can not. In my larger revolvers I count on 125 grain 357 magnums.
Muzzle blast could be a big concern in an auto for me less of a concern in a home.