I have a Ruger sp 101 3 1/16th " revolver in 357. I shoot 38's at the range but always follow up with some 357's. It is more acurate with them but the sting after 20 or more is noticeably more than the 38's. It is quite a handful if you are not use to it. 357 in 110 grain are mild.and easy to handle. Get the 357 and shoot 38's if you need to. at least you will have the option of 357. when I carry CW I always have the hornaday 357 hollowpoints with the polymer filled tips. They are called critical defense. anyway it is like having 2 guns.