Everything is a matter of personal preference. I love my .45 ACP/AR wheelguns, but I prefer steel, preferably stainless. Of course, they weigh more than the aluminum framed guns. My 25-2, even with a 5” barrel weighs 45.5 oz. while my 625PC weighs 42.4 oz. Since I am only using them for range work and don’t have to carry them all day, I find the weight comforting.
I agree about the clips. I either shoot .45 ACP without clips, or shoot .45 Auto Rim. The newer guns allegedly have slightly longer chambers than in days of old, so they can get FTF. I cure that with a longer firing pin. With frame mounted firing pins they are really easy to change.
I may be wrong, but I don’t believe in the durability of alloy framed guns. My alloy guns are .357s. They are intended as “carry much, shoot little” guns. While I like the safety factor of having a gun rated for .357, I shoot much milder loads in them. Recoil with full power loads is worse than my .500 S&W Mags. I have steel frame guns for high round counts.