Easy question for me~Ruger Super Blackhawk or Blackhawk.
My druthers: A Three Screw Super Blackhawk in .44 Magnum. Though I have my "Super" Blackhawks in .45 Colt also. These are Blackhawks set up with the Super Blackhawk grip frame. Also set up my Super Blackhawks with the Blackhawk hammer.
These my pet .44s:
And, here a couple of New Model .45s:
Yep, thats my pick.