Ohhhh the dreaded "wife" question!! My wife almost spells her name Mike, but with an extra "e", it'd Dutch. Mike, you haven't been talking to my wife and are trying to convince me that I don't need the safe full of guns that I have, have you?
If I had to go with the bare essentials, I'd go with the following:
Pistol - Glock 32C Plenty of mags, good reliability
Shotgun - Winchester 1300 A good shotty is worth its weight in gold
Rifle - DSA FAL .308 You can do pretty much anything with a .308
I only have two guns. A Ruger Mark III 22 and a Springfield Loaded 45. Both are set up for bullseye competition, with red dots installed. Though I suppose the 45 could work for HD should the need arise. I could also hunt small game with the 22 as well......from a bench rest I can consistently hit a two litter bottle at 100 yards with it.