Yes. First off, anything is possible.
What type of gun you have and are the fixed sights, front and rear, in dovetails will make a difference. If so, a gunsmith can easily make the change. It'll probably cost you about $30 plus the cost of the new sights. If there is not a dovetail for the front sight like my former Springfield Champion GI, then the Smith will have to machine in a dovetail to the slide. This will cost about $85 plus the cost of the new sights. Most everyone recommends all of this work being done by a Smith to assure proper alignment.